A Few Tools For lncRNA Research

 With the development of technology and research, lncRNA started to play an important role in many research fields, especially the medical research. It is known that lncRNA is related to many diseases, so researchers started to do research on lncRNA.
Useful tools are necessary. Except the basic lncRNA sequencing technology, some analysis tools are also needed, such as some identification tools and gene location tools. Here I summarized some useful tools.

StarBase: http://starbase.sysu.edu.cn/
This platform is the most comprehensive internet system of miRNA, lncRNA, and circRNA based on the CLIP-Seq data. It constructs the regulatory network of ceRNA, and provides the identification tool of lncRNA. StarBase was published in 2011, and was quoted for hundred times.

StarScan: http://mirlab.sysu.edu.cn/starscan  
The identification software based on the degradome sequencing of different kinds of small RNA, target lncRNA, circRNA, pseudogen and mRNA of plants and animals. It has integrated degradome sequencing data of twenty kinds of species. StarScan can identify different types of target small RNA, which includes the lncRNA, circRNA encoding gene and pseudogene.

DIANA-LncBase: www.microrna.gr/LncBase
It is the regulation relationship of miRNA and lncRNA based on the single CLIP-Seq data and computational identification.

miRcode: http://www.mircode.org/mircode/
A software can identify target spot of miRNA which was invented by researchers from University of Gothenburg. It contains the integrated transcriptome annotated by GENECODE, including 10,419 registered lncRNA.

linc2GO: http://www.bioinfo.tsinghua.edu.cn/~liuke/Linc2GO/index.html
The functional annotation database of lncRNA created by Tsinghua University. However, the tools only based on computer will lead to high false positive. It can only be used as an auxiliary tool.

ChipBase: http://deepbase.sysu.edu.cn/chipbase/
You can find transcription factors which have regulation functions on lncRNA expression. If you want to have a look at the expression pattern of lncRNA in normal organism, you can check the expression pattern of lnRNA based on RNA-Seq in ChipBase(http://deepbase.sysu.edu.cn/chipbase/expression.php)

UCSC Genome Browse: http://genome.ucsc.edu/cgi-bin/hgGateway
If you know the chromosome location of the lncRNA, and you want to find the gene name of Ensembl/refSeq and gene symbol. If you are not familiar with it, you can try the software of UCSC, blat( http://genome.ucsc.edu/cgi-bin/hgBlat?command=start ). And if you want to learn how to used the UCSC Genome Browser, you can find it here: http://www.openhelix.com/ucsc

What Is Your “Organic Age”? Let Research Speak

As another exploration, scientists can focus somebody's organic age by perusing 150 of his qualities. Additionally, the natural age can mirror the well-being state of this individual. 

This postulation was distributed on Genome science, named A novel multi-tissue RNA demonstrative of sound maturing identifies with psychological well-being status. In this study, analysts examined the RNA of 65-year old men healthy with a transcriptomics approach. Scientists attempted to discover some biomarkers, trusting those biomarkers are identified with the well-being state of those old men. Researcher discovered 150 qualities and set a technique to figure the maturing quality score. Furthermore, old men with more noteworthy maturing quality score improve psychological well-being. They likewise observed that this maturing quality score is identified with Alzheimer's illness. 

From this study, we can view Alzheimer's malady as quickened maturing. Be that as it may, it still obscure for if this maturing quality score can be utilized to anticipate Alzheimer's infection, the analysts wrote in the proposition. 

Alzheimer's ailment is difficult to be analyzed in the first stage. The principle side effect of Alzheimer's malady is dysmnesia and psychological hindrance. As of recently researchers still can not locate a successful approach to analyze Alzheimer's illness. This exploration gives a probability to AD analysis. What's more, it likewise contributes a considerable measure to the therapeutic examination of AD. 

Also, with the developing of sub-well-being populaces, the organic age steadily assumes a vital part in our well-being condition. As per a few studies, numerous youngsters are in a sub-well-being state. Their natural age is much more noteworthy than their sequential age. The working weight, unpredictable dozing examples, without a standard day by day activity and unscientific eating routine has extraordinary reactions on our body sound and working. Be that as it may, few individuals know exactly about their own particular well-being conditions. 

The maturing quality score can be helpful here. The main thing you have to do is to figure your maturing quality score, know your organic age and discover your well-being condition. This can be utilized to keep us from numerous sicknesses.